Technical Grade, Oral Grade, Injection Grade Hydroxypropyl Beta Cyclodextrin Hpbcd/Hpcd CAS 128446
Basic Info.
Model NO. | py0037 |
Transport Package | Drum |
Specification | 25kg/drum |
Trademark | puya |
Origin | China |
HS Code | 3001200020 |
Production Capacity | 5000kg/Month |
Product Description
Technical grade, oral grade, injection grade Hydroxypropyl Beta Cyclodextrin Hpbcd/Hpcd CAS 128446-35-5Hydroxypropyl-β-cyclodextrin is less toxic than the parent cyclodextrin, is non-toxic orally, and has low hemolytic properties.
Proven for oral and injection through a large number of animal experiments and clinical trials
Hydroxypropyl beta-cyclodextrin are purified polydisperse products resulting from the controlled reaction of oxide and native beta-cyclodextrin.
Hydroxypropyl beta-cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound.
Product Name | Hydroxypropyl-beta-cyclodextrin |
CAS No. | 128446-35-5 |
Appearance | White Powder |
Purity | 98.0% --101.0% |
MF | C105H196O56 |
Molecular weight | 2354.64614 |
Quality standard | USP43-NF38 |
Standard | CP, USP, EP |
Other Grade | Oral Medicine grade, technical grade, Injection grade |
Inspection items | CP2015 | USP43-NF38 |
character | This product is white or nearly white amorphous or crystalline powder; odorless, slightly sweet; strong moisture absorption. Verysoluble in water, soluble in ethanol. | This product is white or nearly white amorphous or crystalline powder; soluble in water . |
Molar substitution degree | N/A | 0.4-1.5 |
PH value | PH5.0-7.5 | N/A |
Clarity and color of solution | It should be clear and colorless | 1.0g/2ml aqueous solution is clear and transparent |
Water content | ≤6.0% | ≤10.0% |
Chloride | ≤0.05% | N/A |
Beta cyclodextrin | ≤0.5% | ≤1.5% |
1.2-propanediol | ≤0.5% | ≤2.5% |
Residue on ignition | N/A | ≤1.0% |
Heavy metal | ≤0.001% | N/A |
Hydroxypropyloxy content | 19.6%~26.3% | N/A |
Total aerobic bacteria (CFU / g) | N/A | ≤1000cfu/g |
Total number of mould and yeast (CFU / g) | N/A | ≤100 cfu/g |
Bacterial endotoxin (EU / g) | N/A | According to the needs of the preparation |
Function
Hydroxypropyl beta-cyclodextrin are purified polydisperse products resulting from the controlled reaction of pro oxide and native beta-cyclodextrin. Hydroxypropyl beta-cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound.
Application
In PharmaceuticalsHydroxypropyl beta cyclodextrin is a solution to insoluble or low solubility drugs(including plant extracts).Through molecular encapsulation,it could increase the drug solubility and control the release rate of the drug,increase the drug's bioavailability and reduce the toxic side-effets.1. Suitable for parenteral use, syrups, solutions and oral suspensions as well as for dry formulations (with possibility of in-situ encapsulation).2. To increase water solubility of poorly soluble drugs.3. To increase bioavailability.4. To improve organoleptic properties of bitter or unpleasant actives.In CosmeticsHydroxypropyl beta cyclodextrin used as stabilizer,emulsifier and odor absorber.It could reduce organic molecules stimulation to skin mucosal and enhance the stability of the effective components.Prevent volatile ,oxidation of nutrient composition ,increase the solubility of insoluble flavours and fragrances and keep the fragrance slow releasing and lasting.1. Suitable for encapsulation of volatile compounds.2. To increase shelf life of expensive flavours